1. Lancet Neurol. 2017 Jul;16(7):552-563. doi: 10.1016/S1474-4422(17)30157-6. Epub 2017 Jun 13.
Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches.
Boxer AL1, Yu JT2, Golbe LI3, Litvan I4, Lang AE5, Höglinger GU6.
PMID: 28653647



1. NPJ Parkinsons Dis. 2017 Jun 29;3:22. doi: 10.1038/s41531-017-0023-3. eCollection 2017.
Imaging tau pathology in Parkinsonisms.
Coakeley S1,2, Strafella AP1,2,3.
PMCID: PMC5491530
PMID: 28685158

2. Parkinsonism Relat Disord. 2017 Jun 27. pii: S1353-8020(17)30224-9. doi: 10.1016/j.parkreldis.2017.06.017. [Epub ahead of print]
Neurophysiological studies on atypical parkinsonian syndromes.
Bologna M1, Suppa A1, Di Stasio F2, Conte A1, Fabbrini G1, Berardelli A3.
PMID: 28669454


1. Sci Rep. 2017 Jul 13;7(1):5357. doi: 10.1038/s41598-017-05575-8.
Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry.
Stemplewitz B1, Kromer R2, Vettorazzi E3, Hidding U4, Frings A2, Buhmann C4.
PMID: 28706282

2. Neurosci Res. 2017 Jul 10. pii: S0168-0102(17)30232-8. doi: 10.1016/j.neures.2017.06.008. [Epub ahead of print]
Diagnosis of Parkinson’s disease and the level of oxidized DJ-1 protein.
Yamagishi Y1, Saigoh K2, Saito Y3, Ogawa I1, Mitsui Y1, Hamada Y1, Samukawa M1, Suzuki H1, Kuwahara M1, Hirano M1, Noguchi N3, Kusunoki S1.
PMID: 28705587

3. Clin Neurophysiol. 2017 Jun 27;128(9):1547-1552. doi: 10.1016/j.clinph.2017.06.032. [Epub ahead of print]
Reversal of long term potentiation-like plasticity in primary motor cortex in patients with progressive supranuclear palsy.
Bologna M1, Bertram K2, Paparella G3, Papi C3, Belvisi D4, Conte A1, Suppa A1, Williams DR5, Berardelli A6.
PMID: 28704733

4. Neurol Clin Neurosci. 2017 May;5(3):86-90. doi: 10.1111/ncn3.12122. Epub 2017 Apr 17.
Freezing of gait is an early clinical feature of progressive supranuclear palsy.
Osaki Y1, Morita Y1, Miyamoto Y1, Furuta K2, Furuya H1.
PMCID: PMC5484990
PMID: 28702192

5. Ann Clin Transl Neurol. 2017 Jun 7;4(7):466-477. doi: 10.1002/acn3.421. eCollection 2017 Jul.
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
McFerrin MB1, Chi X2,3, Cutter G2, Yacoubian TA1 .
PMCID: PMC5497531 Free PMC Article
PMID: 28695147

6. Neuropathology. 2017 Jul 9. doi: 10.1111/neup.12394. [Epub ahead of print]
Pick’s disease with neuronal four-repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum.
Ikeda C1, Yokota O1,2,3, Miki T1,2,3, Takenoshita S1, Ishizu H2, Mori Y4, Yamazaki K4, Ozaki Y4, Ueno SI4, Ishihara T5, Hasegawa M6, Terada S1, Yamada N1.
PMID: 28691164

7. Neuroradiology. 2017 Jul 8. doi: 10.1007/s00234-017-1870-7. [Epub ahead of print]
Differential diagnosis of parkinsonism by a combined use of diffusion kurtosis imaging and quantitative susceptibility mapping.
Ito K1, Ohtsuka C2, Yoshioka K3, Kameda H4, Yokosawa S5, Sato R5, Terayama Y2, Sasaki M6.
PMID: 28689259


1. Ther Deliv. 2017 Jul;8(8):607-613. doi: 10.4155/tde-2017-0063.
An industry update: what is the latest news in therapeutic delivery?
Simpson I1.
PMID: 28730936

※ブリストル・マイヤーズ スクイブの治験薬がバイオジェンに導出されたニュースも紹介されています。

This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites.

Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy.

2. Cold Spring Harb Perspect Biol. 2017 Jul 17. pii: a033118. doi: 10.1101/cshperspect.a033118. [Epub ahead of print]
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.
Erkkinen MG1, Kim MO1, Geschwind MD1.
PMID: 28716886


1. J Geriatr Psychiatry Neurol. 2017 Jan 1:891988717720300. doi: 10.1177/0891988717720300. [Epub ahead of print]
High Burden and Depression Among Late-Stage Idiopathic Parkinson Disease and Progressive Supranuclear Palsy Caregivers.
Schmotz C1,2, Richinger C1,2, Lorenzl S1,2,3.
PMID: 28747135

2. Eur Neurol. 2017 Jul 26;78(3-4):119-124. doi: 10.1159/000479227. [Epub ahead of print]
Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism.
Lee SH1, Lyoo CH1, Cho H1, Rinne JO2, Lee MS1.
PMID: 28746923

3. Front Neurol. 2017 Jul 11;8:321. doi: 10.3389/fneur.2017.00321. eCollection 2017.
Novel Eye Movement Disorders in Whipple’s Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia.
Shaikh AG1,2,3,4, Ghasia FF1,5.
PMCID: PMC5504231 Free PMC Article
PMID: 28744253


1. J Neurol. 2017 Jul 31. doi: 10.1007/s00415-017-8579-8. [Epub ahead of print]
Regional microstructural damage and patterns of eye movement impairment: a DTI and video-oculography study in neurodegenerative parkinsonian syndromes.
Gorges M1, Maier MN1, Rosskopf J1, Vintonyak O1, Pinkhardt EH1, Ludolph AC1, Müller HP1, Kassubek J2.
PMID: 28762086

2. Neurology. 2017 Jul 28. pii: 10.1212/WNL.0000000000004264. doi: 10.1212/WNL.0000000000004264. [Epub ahead of print]
In vivo retention of 18F-AV-1451 in corticobasal syndrome.
Smith R1, Schöll M2, Widner H2, van Westen D2, Svenningsson P2, Hägerström D2, Ohlsson T2, Jögi J2, Nilsson C2, Hansson O1.
PMID: 28754841


1. J Assoc Physicians India. 2017 Aug;65(8):32-37.
Clinical Profile of Dysphagia in Patients with Parkinson’s Disease, Progressive Supranuclear Palsy and Multiple System Atrophy.
Sulena1, Gupta D2, Sharma AK3, Singh B4.
PMID: 28799303

2. Parkinsonism Relat Disord. 2017 Aug 1. pii: S1353-8020(17)30278-X. doi: 10.1016/j.parkreldis.2017.07.031. [Epub ahead of print]
Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration.
Ling H1.
PMID: 28789904

3. Curr Neurol Neurosci Rep. 2017 Sep;17(9):72. doi: 10.1007/s11910-017-0779-1.
Emerging Diagnostic and Therapeutic Strategies for Tauopathies.
Coughlin D1,2, Irwin DJ3.
PMID: 28785992

4. J Mov Disord. 2017 Aug 8. doi: 10.14802/jmd.17025. [Epub ahead of print]
‘Hummingbird’ Sign in a Patient with Guam Parkinsonism-Dementia Complex.
Yeo T1, Tan LC1.
Free Article
PMID: 28782342

5. Parkinsonism Relat Disord. 2017 Aug 1. pii: S1353-8020(17)30280-8. doi: 10.1016/j.parkreldis.2017.07.033. [Epub ahead of print]
Neuropathology of Parkinson disease.
Dickson DW1.
PMID: 28780180

6. Sleep Med Clin. 2017 Sep;12(3):443-460. doi: 10.1016/j.jsmc.2017.03.017. Epub 2017 Jun 16.
Hypersomnia in Neurodegenerative Diseases.
Bhat S1, Chokroverty S2.
PMID: 28778241


1. Neuropsychiatr Dis Treat. 2017 Aug 2;13:2057-2067. doi: 10.2147/NDT.S130475. eCollection 2017.
La belle indifférence revisited: a case report on progressive supranuclear palsy misdiagnosed as conversion disorder.
van Meerkerk-Aanen PJ1, de Vroege L1,2, Khasho D1, Foruz A1, van Asseldonk JT3, van der Feltz-Cornelis CM1,2.
PMCID: PMC5546807
PMID: 28814874

2. Int Rev Neurobiol. 2017;134:1285-1301. doi: 10.1016/bs.irn.2017.06.001. Epub 2017 Jul 3.
Nonmotor Features in Atypical Parkinsonism.
Bhatia KP1, Stamelou M2.
PMID: 28805573

3. Eur J Neurol. 2017 Aug 12. doi: 10.1111/ene.13412. [Epub ahead of print]
Atypical Parkinsonian syndromes: a general neurologist’s perspective.
Deutschländer AB1,2,3, Ross OA2,3, Dickson DW2, Wszolek ZK1.
PMID: 28803444


1. Toxicon. 2017 Aug 21. pii: S0041-0101(17)30263-5. doi: 10.1016/j.toxicon.2017.08.018. [Epub ahead of print]
Botulinum toxin in parkinsonism: The when, how, and which for botulinum toxin injections.
Cardoso F1.
PMID: 28837826

2. Sci Rep. 2017 Aug 22;7(1):9115. doi: 10.1038/s41598-017-09481-x.
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression.
Lachén-Montes M1, González-Morales A1, Zelaya MV1,2,3, Pérez-Valderrama E4, Ausín K4, Ferrer I5, Fernández-Irigoyen J1,2,4, Santamaría E6,7,8.
Free Article
PMID: 28831118
ミトコンドリア蛋白のプロヒビチン(prohibitin, PHB)のPhb1とPhb2の発現状況は,アルツハイマー病,FTLD,PSPではそれぞれ異なった。

3. Clin Neurophysiol. 2017 Jul 17;128(10):1978-1984. doi: 10.1016/j.clinph.2017.06.257. [Epub ahead of print]
Pain processing in atypical Parkinsonisms and Parkinson disease: A comparative neurophysiological study.
Avenali M1, Tassorelli C2, De Icco R2, Perrotta A 3, Serrao M4, Fresia M5, Pacchetti C6, Sandrini G2.
PMID: 28829981

1. Mov Disord. 2017 Aug 26. doi: 10.1002/mds.27125. [Epub ahead of print]
Clinicopathologic discrepancies in a population-based incidence study of parkinsonism in olmsted county: 1991-2010.
Turcano P1, Mielke MM1,2, Josephs KA1, Bower JH1, Parisi JE1,3, Boeve BF1, Savica R1,2.
PMID: 28843020


1. Brain Struct Funct. 2017 Sep 7. doi: 10.1007/s00429-017-1507-y. [Epub ahead of print]
[18F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP.
Coakeley S1,2, Cho SS1,2, Koshimori Y1,2, Rusjan P1, Ghadery C1,2, Kim J1,2, Lang AE3, Houle S1, Strafella AP4,5,6.
PMID: 28884232
※[18F] AV-1451(異常タウ蛋白に結合するように設計されたPETトレーサー)に関するカナダの原著論文

2. Iran J Child Neurol. 2017 Summer;11(3):53-56.
The Report of Three Rare Cases of the Niemann-pick Disease in Birjand, South Khorasan, Eastern Iran.
Noroozi Asl S1, Vakili R2, Ghaemi N1, Eshraghi P1.
PMID: 28883878

3. Neurodegener Dis. 2017 Sep 8;17(6):286-291. doi: 10.1159/000479110. [Epub ahead of print]
Mild Cognitive Impairment and Progression to Dementia in Progressive Supranuclear Palsy.
Pilotto A1, Gazzina S, Benussi A, Manes M, Dell’Era V, Cristillo V, Cosseddu M, Turrone R, Alberici A, Padovani A, Borroni B.
PMID: 28881351

4. Neurol India. 2017 Sep-Oct;65(5):1083-1090. doi: 10.4103/neuroindia.NI_880_16.
Review of tremor in Parkinson’s disease and atypical parkinsonian disorders.
Mailankody P1, Netravathi M1, Pal PK1.
PMID: 28879902

5. Front Neurol. 2017 Aug 23;8:429. doi: 10.3389/fneur.2017.00429. eCollection 2017.
Clinical Approach to Supranuclear Brainstem Saccadic Gaze Palsies.
Lloyd-Smith Sequeira A1, Rizzo JR1,2, Rucker JC1,3.
PMCID: PMC5572401 Free Article
PMID: 28878733
※supranuclear saccadic gaze palsy(SGP,核上性衝動性注視麻痺)に関する米国の総説

6. Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201701517. doi: 10.1073/pnas.1701517114. [Epub ahead of print]
Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood.
Paraskevaidi M1, Morais CLM2, Lima KMG2, Snowden JS3, 4, Saxon JA3,4, Richardson AMT3,4, Jones M3,4, Mann DMA4, Allsop D5, Martin-Hirsch PL6, Martin FL1.
Free Article
PMID: 28874525
PSP患者も対象。AD; n = 164,FTD; n = 30,PD; n = 32,PSP; n = 31

7. Geriatr Psychol Neuropsychiatr Vieil. 2017 Sep 1;15(3):285-294. doi: 10.1684/pnv.2017.0686.
Structural magnetic resonance imaging in frontotemporal lobar dementia.
Bertrand A1, Stroër S1, Le Ber I2, Teichmann M3, Dormont D1.
PMID: 28872040

8. J Neurol Sci. 2017 Sep 15;380:182-186. doi: 10.1016/j.jns.2017.07.033. Epub 2017 Jul 24.
Executive dysfunction, behavioral changes and quality of life in Chinese patients with progressive supranuclear palsy.
Ou R1, Liu H1, Hou Y1, Wei Q1, Cao B1, Zhao B1, Shang H2.
PMID: 28870563


1. J Nucl Med. 2017 Sep 14. pii: jnumed.116.186403. doi: 10.2967/jnumed.116.186403. [Epub ahead of print]
18F-FDG PET in Parkinsonism: Differential Diagnosis and Cognitive Impairment in Parkinson’s disease.
Meyer PT1, Frings L2, Rücker G3, Hellwig S4.
PMID: 28912150

2. Neuropathology. 2017 Sep 14. doi: 10.1111/neup.12429. [Epub ahead of print]
Neuropathological comorbidity associated with argyrophilic grain disease.
Yokota O1,2, Miki T1,2, Ikeda C2,3, Nagao S2,4, Takenoshita S2, Ishizu H5, Haraguchi T6, Kuroda S5, Terada S2, Yamada N2.
PMID: 28906054
※日本のきのこエスポアール病院(岡山県)や 岡山大学大学院医歯薬学総合研究科の先生方の論文
嗜銀性顆粒病. (argyrophilic grain disease, AGD)に関する論文。AGDは4リポートタウオパチー。他の疾患と併存することがあり,PSP症例におけるAGDの頻度は18.8%〜80%の範囲であると報告されている。CBD症例におけるAGDの頻度は,PSP症例よりも高い傾向があり,41.2%から100%の範囲である。

大脳皮質基底核変性症における嗜銀性顆粒の検討 – 新潟大学脳研究所

3. Radiol Bras. 2017 Jul-Aug;50(4):250-257. doi: 10.1590/0100-3984.2016-0073.
The role of diffusion magnetic resonance imaging in Parkinson’s disease and in the differential diagnosis with atypical parkinsonism.
de Oliveira RV1, Pereira JS2.
PMCID: PMC5586516 Free PMC Article
PMID: 28894333

4. Ann Neurol. 2017 Sep 11. doi: 10.1002/ana.25046. [Epub ahead of print]
Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration.
Espay AJ1, Da Prat GA1,2, Dwivedi AK3, Rodriguez-Porcel F1, Vaughan JE1, Rosso M1, Devoto JL1, Duker AP1, Masellis M4, Smith CD5, Mandybur JGT6, Merola A1, Lang AE7.
PMID: 28892572

5. Parkinsonism Relat Disord. 2017 Sep 1. pii: S1353-8020(17)30319-X. doi: 10.1016/j.parkreldis.2017.08.029. [Epub ahead of print]
Quantitative susceptibility mapping differentiates between parkinsonian disorders.
Sjöström H1, Granberg T2, Westman E3, Svenningsson P4.
PMID: 28886909

※鑑別診断のための定量的磁化率マッピング(quantitative susceptibility mapping,QSM)に関するスウェーデンの原著論文